Biological performance of a novel bovine hydroxyapatite in a guided bone regeneration model: A preclinical study in a mandibular defect in dogs

Published in October 2023 - Clinical Implant Dentistry & Related Research - This preclinical model study aimed to evaluate the performance and safety of a novel hydroxyapatite biomaterial (Wishbone Hydroxyapatite, WHA) on guided bone regeneration compared to a commercially available deproteinised bovine bone mineral (Bio-Oss, BO).

The study concluded WHA and BO resulted in similar at 12 and 26 weeks, with higher regenerative performance when compared to the sham controls. However, at 4 weeks, the defect regeneration was significantly enhanced by WHA compared to all other treatments. WHA showed excellent safety and biocompatibility at all three timepoints, which was comparable to that of BO.

Effect of Sintering on In Vivo Biological Performance of Chemically Deproteinized Bovine Hydroxyapatite

The influence of the manufacturing process on physicochemical properties and biological performance of xenogenic biomaterials has been extensively studied, but its quantification on bone-to-material contact remains poorly investigated. The aim of this study was to investigate the effect of different heat treatments of an experimental chemically deproteinized bovine hydroxyapatite in vivo in terms of new bone formation and osteoconductivity.